Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | ATR | Q13535 | 4/20 | 0.33 |
| ▸ | NEK2 | P51955 | 5/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12078764 | 0.84 | PIK3CG (0.44) | ATR | |
| SCHEMBL12495768 | 0.77 | MAP4K4 (0.40) | NPY5RATRNEK2TYRO3FGFR1 | |
| SCHEMBL12495678 | 0.73 | MAP4K4 (0.38) | MAPK1ATR | |
| SCHEMBL12495701 | 0.73 | KCNH2 (0.46) | ATRTYRO3 | |
| SCHEMBL12496272 | 0.70 | KCNH2 (0.58) | — | |
| SCHEMBL18936948 | 0.70 | PIK3CG (0.43) | ATR | |
| SCHEMBL12495821 | 0.69 | KCNH2 (0.45) | ATRTYRO3 | |
| SCHEMBL12496252 | 0.68 | KCNH2 (0.44) | ATRTYRO3 | |
| SCHEMBL18937005 | 0.66 | NOS1 (0.38) | MAPK1ATRNEK2TYRO3 | |
| SCHEMBL12496015 | 0.65 | GSK3B (0.44) | MAPK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |