Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.58 |
| ▸ | CTRL | P40313 | 1/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.57 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.57 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.57 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.57 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.57 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.57 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.57 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.57 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.57 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.57 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.57 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17706113 | 1.00 | HTT (0.59) | HTTUSP2TMPRSS11DCTRLPSMB5 | |
| SCHEMBL31013619 | 0.90 | HTT (0.56) | HTTUSP2TMPRSS11DCTRLPSMB5 | |
| SCHEMBL16081640 | 0.90 | HTT (0.56) | HTTUSP2TMPRSS11DCTRLPSMB5 | |
| SCHEMBL18286847 | 0.90 | TMPRSS11D (0.61) | HTTUSP2TMPRSS11DCTRLPSMB5 | |
| SCHEMBL16228174 | 0.90 | TMPRSS11D (0.59) | HTTTMPRSS11DCTRLPSMB5CYP3A4 | |
| SCHEMBL16228176 | 0.90 | TMPRSS11D (0.59) | HTTTMPRSS11DCTRLPSMB5CYP3A4 | |
| SCHEMBL20825471 | 0.89 | TMPRSS11D (0.66) | HTTTMPRSS11DCTRLPSMB5CYP3A4 | |
| SCHEMBL20825237 | 0.89 | TMPRSS11D (0.75) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL19851642 | 0.89 | TMPRSS11D (0.75) | TMPRSS11DCTRLPSMB5CYP3A4CYP3A5 | |
| SCHEMBL17706123 | 0.88 | MMP12 (0.58) | HTTUSP2TMPRSS11DCTRLPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098532-A1 | CRYSTALLINE AND AMORPHOUS FORMS OF CARFILZOMIB | MYLAN LABORATORIES LIMITED (IN) | 2017-06-15 | — | — | WO | disclosed |