Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676761 | 0.86 | KMT2A (0.61) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL1696947 | 0.84 | KMT2A (0.58) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18970421 | 0.84 | KMT2A (0.61) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL18970229 | 0.83 | KMT2A (0.76) | KMT2AMEN1HSD17B2PDK1ACHE | |
| SCHEMBL1691800 | 0.83 | KMT2A (0.57) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18970230 | 0.82 | KMT2A (0.61) | KMT2AMEN1HSD17B2HSD17B1HPGD | |
| SCHEMBL18773985 | 0.82 | KMT2A (0.58) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18717447 | 0.82 | MEN1 (0.52) | KMT2AMEN1HSD17B2HSD17B1PDK1 | |
| SCHEMBL18719892 | 0.81 | PLAU (0.42) | KMT2AMEN1HSD17B2F10HTR2A | |
| SCHEMBL18970415 | 0.80 | KMT2A (0.59) | KMT2AMEN1HSD17B2HSD17B1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166560-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166560-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | KMT2A 2123/4885MEN1 1384/4885HSD17B2 1942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.