Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9762519 | 0.87 | HDAC7 (0.47) | TSHRUSP2NPSR1CA1CA2 | |
| SCHEMBL11405604 | 0.80 | TSHR (0.41) | TSHRUSP2HTTNPSR1CA1 | |
| SCHEMBL8239369 | 0.79 | — | — | |
| SCHEMBL20824847 | 0.77 | CA2 (0.44) | CA1CA2L3MBTL1HDAC7HDAC8 | |
| SCHEMBL4372112 | 0.73 | SLC1A2 (0.46) | TSHRHDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL1899213 | 0.72 | — | — | |
| SCHEMBL20208670 | 0.71 | HSD17B10 (0.40) | TSHRCA1CA2LMNAL3MBTL1 | |
| SCHEMBL16590592 | 0.70 | MCL1 (0.50) | TSHRUSP2HTTNPSR1CA1 | |
| SCHEMBL6871426 | 0.69 | — | — | |
| SCHEMBL12864235 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114577927-A | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2022-06-03 | — | — | CN | claimed |
| CN-105237437-A | Entacapone impurity compound and preparation method thereof | CHONGQING ZHIEN PHARMACEUTICAL CO LTD | 2016-01-13 | — | — | CN | claimed |
| CN-104744301-A | Method for producing entacapone | LI LEI | 2015-07-01 | — | — | CN | claimed |
| CN-104402764-A | Preparation method for entacapone | CHEER FINE PHARMACEUTICAL ANHUI CO LTD | 2015-03-11 | — | — | CN | claimed |
| EP-2054379-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | Alembic Limited (IN) | 2009-05-06 | — | — | EP | claimed |
| WO-2008062432-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | ALEMBIC LIMITED (IN) | 2008-05-29 | — | — | WO | claimed |
| WO-2007113845-A1 | A PROCESS FOR THE PREPARATION OF (E)-2-CYANO-3-(3, 4-DIHYDROXY-5-NITROPHENYL)-N, N-DIETHYL-2-PROPENAMIDE (ENTACAPONE) | ALEMBIC LIMITED (IN) | 2007-10-11 | — | — | WO | claimed |
| CN-114577927-B | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-108440340-B | Method for preparing entacapone | 北京伊斯康科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-114577927-A | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-114577927-A | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-114276605-A | High-temperature-resistant halogen-free flame-retardant cable and preparation process thereof | 温州网牌电线电缆有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-109286041-B | Electrolyte and secondary lithium battery | 宁德时代新能源科技股份有限公司 | 2020-12-11 | — | — | CN | disclosed |
| WO-2008062432-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | ALEMBIC LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008062432-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | ALEMBIC LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007113845-A1 | A PROCESS FOR THE PREPARATION OF (E)-2-CYANO-3-(3, 4-DIHYDROXY-5-NITROPHENYL)-N, N-DIETHYL-2-PROPENAMIDE (ENTACAPONE) | ALEMBIC LIMITED (IN) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007113845-A1 | A PROCESS FOR THE PREPARATION OF (E)-2-CYANO-3-(3, 4-DIHYDROXY-5-NITROPHENYL)-N, N-DIETHYL-2-PROPENAMIDE (ENTACAPONE) | ALEMBIC LIMITED (IN) | 2007-10-11 | — | — | WO | disclosed |
| EP-1701936-A4 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | WOCKHARDT LTD (IN) | 2007-01-24 | — | — | EP | disclosed |
| EP-1701936-A1 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | Wockhardt Limited (IN) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005070881-A1 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | WOCKHARDT LIMITED (IN) | 2005-08-04 | — | — | WO | disclosed |