Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897128 | 0.87 | TSHR (0.50) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL20824847 | 0.78 | CA2 (0.44) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL20208670 | 0.78 | HSD17B10 (0.40) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL18664332 | 0.74 | HDAC7 (0.54) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL18664295 | 0.74 | HDAC7 (0.54) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL11393546 | 0.73 | CA2 (0.51) | CA2CA1TSHRL3MBTL1CA7 | |
| SCHEMBL12790571 | 0.72 | HDAC8 (0.52) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL8239369 | 0.72 | — | — | |
| SCHEMBL19188339 | 0.72 | TSHR (0.54) | HDAC7HDAC8HDAC6HDAC9HDAC5 | |
| SCHEMBL10437117 | 0.72 | HDAC7 (0.52) | HDAC7HDAC8HDAC6HDAC9HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064825-A | Hypotensive agents; treatment of congestive heart failure | MERCK & CO., INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0401030-A2 | Angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |