Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | MME | P08473 | 4/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18973023 | 0.85 | ESR1 (0.44) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL13821889 | 0.83 | ACE (0.48) | MAPTGAACRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL19700517 | 0.81 | FOLH1 (0.45) | ACEMMECPA1ACE2 | |
| SCHEMBL23135666 | 0.80 | CTSL (0.44) | ACEMMECPA1ACE2 | |
| SCHEMBL18879461 | 0.79 | GRIA1 (0.44) | ACEMMECPA1ACE2 | |
| SCHEMBL23026392 | 0.79 | CTSL (0.49) | ACEMMECPA1ACE2 | |
| SCHEMBL20099253 | 0.77 | ACE (0.46) | ACEMMECPA1ACE2 | |
| SCHEMBL22692612 | 0.75 | CTSL (0.40) | ACEMMECPA1ACE2 | |
| SCHEMBL1709323 | 0.75 | ESR1 (0.51) | ACEMMECPA1ACE2PPARG | |
| SCHEMBL13101444 | 0.73 | GFER (0.50) | MAPTGAASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994855-B2 | Compositions and methods for modulating growth hormone receptor expression | IONIS PHARMACEUTICALS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170166899-A1 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2017-06-15 | — | — | US | disclosed |