Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 5/20 | 0.42 |
| ▸ | MME | P08473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13821889 | 0.86 | ACE (0.48) | ESR1ESR2PPARGMAPTGAA | |
| SCHEMBL18973012 | 0.85 | MAPT (0.44) | ESR1ESR2PPARGMAPTGAA | |
| SCHEMBL16217879 | 0.79 | GRIA1 (0.44) | ACEMMECPA1ACE2OPRK1 | |
| SCHEMBL21415384 | 0.79 | GRIA1 (0.46) | ESR1ESR2OPRK1 | |
| SCHEMBL16217709 | 0.79 | GRIA1 (0.46) | ESR1ESR2OPRK1 | |
| SCHEMBL16656679 | 0.79 | GRIA1 (0.46) | ESR1ESR2OPRK1 | |
| SCHEMBL13765690 | 0.76 | TSHR (0.62) | MAPTSMN1; SMN2ACEMMEALDH1A1 | |
| SCHEMBL3876493 | 0.75 | CYP1A2 (0.59) | ESR1ESR2PPARGSLC7A5ACE | |
| SCHEMBL3661382 | 0.75 | CYP1A2 (0.59) | ESR1ESR2PPARGSLC7A5ACE | |
| SCHEMBL6379983 | 0.75 | CYP1A2 (0.59) | ESR1ESR2PPARGSLC7A5ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166899-A1 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2017-06-15 | — | — | US | disclosed |