Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | CHRND | Q07001 | 5/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.44 |
| ▸ | CHRNG | P07510 | 1/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24476234 | 0.87 | CTSS (0.51) | CTSLMMEACE | |
| SCHEMBL27334440 | 0.87 | CTSS (0.51) | CTSLMMEACE | |
| SCHEMBL19700517 | 0.86 | FOLH1 (0.45) | GRIA1CTSLOPRD1OPRM1OPRK1 | |
| SCHEMBL16217709 | 0.85 | GRIA1 (0.46) | GRIA1CTSLOPRD1OPRM1OPRK1 | |
| SCHEMBL21415384 | 0.85 | GRIA1 (0.46) | GRIA1CTSLOPRD1OPRM1OPRK1 | |
| SCHEMBL16656679 | 0.85 | GRIA1 (0.46) | GRIA1CTSLOPRD1OPRM1OPRK1 | |
| SCHEMBL15095619 | 0.82 | ESR1 (0.53) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL15336553 | 0.82 | ESR1 (0.53) | FOLH1MMEACECPA1ACE2 | |
| SCHEMBL9968605 | 0.80 | OPRD1 (0.55) | GRIA1CTSLOPRD1OPRM1OPRK1 | |
| SCHEMBL18973023 | 0.79 | ESR1 (0.44) | OPRK1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015168618-A2 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| WO-2014179620-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014179625-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014179629-A2 | COMPOSITIONS AND METHODS | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |