Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103180 | 0.77 | HSD11B1 (0.68) | HSD11B1DDB1CRBNPOLBHTR2C | |
| SCHEMBL1894852 | 0.77 | HSD11B1 (0.55) | HSD11B1PRMT5WDR77DDB1CRBN | |
| SCHEMBL24167463 | 0.68 | HSD11B1 (0.73) | HSD11B1POLB | |
| SCHEMBL28829972 | 0.66 | KDM1A (0.60) | HSD11B1MEN1KMT2ADDB1CRBN | |
| SCHEMBL8022305 | 0.65 | HSD11B1 (0.52) | HSD11B1DDB1CRBNKDM1ARCOR1 | |
| SCHEMBL30823799 | 0.64 | DDB1 (0.56) | HSD11B1MEN1KMT2ADDB1CRBN | |
| SCHEMBL28644757 | 0.64 | DDB1 (0.56) | HSD11B1MEN1KMT2ADDB1CRBN | |
| Hydrochloric Acid SCHEMBL27463785 | 0.64 | HSD11B1 (0.51) | HSD11B1DDB1CRBNKDM1ARCOR1 | |
| SCHEMBL27549150 | 0.64 | KDM1A (0.57) | PRMT5WDR77MEN1KMT2AFAAH | |
| SCHEMBL317942 | 0.62 | DDB1 (0.54) | HSD11B1MEN1KMT2ADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322505-A1 | 1-ADAMANTYLAZETIDIN-2-ONE DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME | Kowa Company, Ltd. (JP) | 2011-05-18 | — | — | EP | claimed |