Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 19/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 19/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 18/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.59 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530718 | 0.91 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973261 | 0.90 | GABRA5 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973268 | 0.90 | GABRA5 (0.65) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973264 | 0.89 | GABRA5 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973331 | 0.88 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL26187850 | 0.87 | GABRA1 (0.72) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973219 | 0.87 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973328 | 0.86 | GABRA1 (0.65) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973208 | 0.86 | GABRA5 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18973241 | 0.85 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017097217-A1 | PHTHALAZINE DERIVATIVES, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2017-06-15 | — | — | WO | disclosed |