Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12289582 | 0.88 | ACHE (0.61) | ACHECHEK2DYRK3MAP4K4PIM1 | |
| SCHEMBL18973762 | 0.80 | KDM4E (0.43) | ACHECHEK2PIM1PIM3KDM4E | |
| SCHEMBL14903464 | 0.79 | ACHE (0.53) | ACHECHEK2DYRK3MAP4K4PIM1 | |
| SCHEMBL20982555 | 0.79 | ACHE (0.59) | ACHECHEK2BRAFATP4AATP4B | |
| SCHEMBL21017655 | 0.79 | ACHE (0.65) | ACHECHEK2KDM4ENPC1ALDH1A1 | |
| SCHEMBL21017232 | 0.79 | ACHE (0.77) | ACHECHEK2BRAFHDAC6ATP4A | |
| SCHEMBL21017221 | 0.77 | ACHE (0.63) | ACHECHEK2DYRK3MAP4K4PIM1 | |
| SCHEMBL21018108 | 0.77 | ACHE (0.69) | ACHECHEK2DYRK3MAP4K4PIM1 | |
| SCHEMBL14891841 | 0.76 | ACHE (0.62) | ACHEDYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL21018152 | 0.75 | ACHE (0.81) | ACHECHEK2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556058-B1 | RADIOPROTECTOR COMPOUNDS AND METHODS | PETER MACCALLUM CANCER INST (AU) | 2017-06-14 | — | — | EP | disclosed |