Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL1897497 | 1.00 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL1996746 | 0.99 | KMT2A (0.63) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL1996751 | 0.99 | KMT2A (0.63) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL22635843 | 0.95 | KMT2A (0.58) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL8634349 | 0.95 | KMT2A (0.68) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL8634348 | 0.95 | KMT2A (0.68) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL6390462 | 0.95 | KMT2A (0.55) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL4961514 | 0.92 | KMT2A (0.53) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL4961509 | 0.92 | KMT2A (0.53) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL28980603 | 0.92 | KMT2A (0.54) | KMT2AKDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496245-B1 | ANALOGS OF PITUTARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | UNIV TULANE (US) | 2016-07-20 | — | — | EP | disclosed |
| US-9353171-B2 | Use of pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP analogs for treating contrast-induced nephropathy | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2016-05-31 | — | — | US | disclosed |
| EP-3019184-A1 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | The Administrators of the Tulane Educational Fund (US) | 2016-05-18 | — | — | EP | disclosed |
| US-20160122406-A1 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | 2016-05-05 | — | — | US | disclosed |
| CN-102215859-B | Use of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and PACAP analogs as adjunctive therapy with anticancer agents | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2016-04-20 | — | — | CN | disclosed |
| US-20150104388-A1 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | 2015-04-16 | — | — | US | disclosed |
| US-8916517-B2 | Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2014-12-23 | — | — | US | disclosed |
| WO-2014197909-A1 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2014-12-11 | — | — | WO | disclosed |
| US-20140314838-A1 | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS FOR TREATING CONTRAST-INDUCED NEPHROPATHY | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | 2014-10-23 | — | — | US | disclosed |
| WO-2013074966-A1 | USE OF PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS FOR TREATING CONTRAST -INDUSED NEPHROPATHY | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2013-05-23 | — | — | WO | disclosed |
| CN-102215859-A | Use of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and PACAP analogs as adjunctive therapy with anticancer agents | UNIV TULANE | 2011-10-12 | — | — | CN | disclosed |
| WO-2011097581-A2 | THE USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH INHIBITORS OF CALCINEURIN OR INHIBITORS OF THE MAMMALIAN TARGET OF RAPAMYCIN (mTOR) COMPLEXES | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2011-08-11 | — | — | WO | disclosed |
| WO-2011054001-A2 | ANALOGS OF PITUTARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE | THE ADMINISTRATORS OF THE TULANE (US) | 2011-05-05 | — | — | WO | disclosed |
| US-20050164969-A1 | Method of extending life span | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-07-28 | — | — | US | disclosed |
| EP-1506292-A1 | PECTATE LYASE VARIANTS | Novozymes A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003095638-A1 | PECTATE LYASE VARIANTS | NOVOZYMES A/S (DK) | 2003-11-20 | — | — | WO | disclosed |
| EP-1305408-A2 | CELL-WALL DEGRADING ENZYME VARIANTS | Novozymes A/S (DK) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002006442-A2 | CELL-WALL DEGRADING ENZYME VARIANTS | NOVOZYMES A/S (DK) | 2002-01-24 | — | — | WO | disclosed |
| US-4713445-A | HYPOTENSIVE AGENTS; NONHYDROLYZING; MEDICAL DIAGNOSIS | AKTIEBOLAGET HASSLE (SE) | 1987-12-15 | — | — | US | disclosed |
| WO-1984003044-A1 | ENZYME INHIBITORS | FERRING AB (SE) | 1984-08-16 | — | — | WO | disclosed |