Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 9/20 | 0.46 |
| ▸ | HTR1A | P08908 | 8/20 | 0.46 |
| ▸ | HTR1D | P28221 | 8/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18975165 | 0.81 | HTT (0.47) | HTTHTR1BHTR1AHTR1DNR4A2 | |
| SCHEMBL18975023 | 0.80 | NR4A2 (0.48) | HTTHTR1BHTR1AHTR1DNR4A2 | |
| SCHEMBL16922679 | 0.76 | NR4A2 (0.65) | NR4A2TDP1KDM4EMEN1KMT2A | |
| SCHEMBL8959903 | 0.74 | TSHR (0.65) | NR4A2MAPK1MAPTTDP1KDM4E | |
| SCHEMBL5935743 | 0.74 | TSHR (0.65) | NR4A2MAPK1MAPTTDP1KDM4E | |
| SCHEMBL27961666 | 0.73 | TSHR (0.66) | NR4A2MAPK1TDP1KDM4ETP53 | |
| SCHEMBL18975022 | 0.73 | TSHR (0.47) | HTR1BNR4A2MAPK1MAPTTDP1 | |
| SCHEMBL12721389 | 0.73 | MAPT (0.71) | HTTHTR1BHTR1AHTR1DNR4A2 | |
| SCHEMBL6989165 | 0.72 | NR4A2 (0.49) | HTTHTR1BHTR1AHTR1DNR4A2 | |
| SCHEMBL6995946 | 0.71 | ALDH1A1 (0.50) | HTTHTR1BHTR1AHTR1DNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | ALPHARMAGEN LLC (US) | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166561-A1 | QUINUCLIDINE COMPOUNDS FOR MODULATING ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | CHRNA7, CHRNA2, CHRNA6 | HTT 711/4885HTR1B 221/4885HTR1A 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.