Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19426931 | 0.84 | GAA (0.36) | GAAPLA2G7HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL24703487 | 0.64 | GRIN2D (0.47) | MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8780920 | 0.64 | GAA (0.46) | GAAPLA2G7HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL16751345 | 0.62 | CA12 (0.32) | HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL25708983 | 0.62 | ALDH1A1 (0.34) | GAAHSD17B10SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL91340 | 0.62 | ALDH1A1 (0.45) | GAAPLA2G7HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL17083422 | 0.61 | ALDH1A1 (0.42) | GAAPLA2G7HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL22521692 | 0.61 | LGMN (0.32) | — | |
| SCHEMBL19157808 | 0.60 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL219172 | 0.60 | ALDH1A1 (0.44) | PLA2G7HSD17B10SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013814-B1 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-14 | — | — | EP | disclosed |