SCHEMBL18976953

SCHEMBL18976953

IN1CCN(CC2CC2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM5 P08912 1/20 0.48
ADRA2C P18825 1/20 0.48
ACHE P22303 1/20 0.41
SCN1A P35498 1/20 0.35
SCN4A P35499 1/20 0.35
SCN7A Q01118 1/20 0.35
KCNH2 Q12809 1/20 0.35
SCN5A Q14524 1/20 0.35
SCN9A Q15858 1/20 0.35
SCN2A Q99250 1/20 0.35
SCN3A Q9NY46 1/20 0.35
SCN11A Q9UI33 1/20 0.35
SCN8A Q9UQD0 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
SIGMAR1 Q99720 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
DRD2 P14416 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22940345 0.92 CHRM5 (0.46) CHRM5ADRA2CACHESIGMAR1SMN1; SMN2
SCHEMBL25803004 0.88 CHRM5 (0.67) CHRM5ADRA2CACHESIGMAR1SMN1; SMN2
SCHEMBL18740713 0.86
SCHEMBL23598108 0.84 CACNA2D1 (0.42) CHRM5ADRA2CACHEDRD2
SCHEMBL22940513 0.84 NCF1 (0.45) CHRM5ADRA2CACHEKCNH2SIGMAR1
SCHEMBL24803106 0.84 CHRM5 (0.40) CHRM5ADRA2CACHESIGMAR1DRD2
SCHEMBL23816122 0.84 CHRM5 (0.40) CHRM5ADRA2CACHESIGMAR1SMN1; SMN2
Hydrochloric Acid SCHEMBL7331633 0.83 CHRM5 (0.57) CHRM5ADRA2CACHESCN1ASCN4A
SCHEMBL23173752 0.83 ACHE (0.42) CHRM5ADRA2CACHESIGMAR1SMN1; SMN2
SCHEMBL23816614 0.83 CHRM5 (0.39) CHRM5ADRA2CACHESIGMAR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4008719-A2 PYRAZOLONE AND PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND USE THEREFOR Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2022-06-08 EP disclosed
EP-3145929-B1 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS HOFFMANN LA ROCHE (CH) 2021-01-13 EP disclosed
WO-2020259724-A2 PYRAZOLONE AND PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND USE THEREFOR 上海医药集团股份有限公司 2020-12-30 WO disclosed
EP-3322706-B1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2020-11-11 EP disclosed
EP-3019493-B1 MODIFIED BET-PROTEIN INHIBITING DIHYDROCHINOXALINONES AND DIHYDROPYRIDOPYRAZINONES Bayer Pharma AG (DE) 2017-06-14 EP disclosed