Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.81 |
| ▸ | ALPI | P09923 | 1/20 | 0.81 |
| ▸ | PKM | P14618 | 1/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.81 |
| ▸ | XIAP | P98170 | 1/20 | 0.81 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.64 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.64 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.64 |
| ▸ | CPA1 | P15085 | 2/20 | 0.59 |
| ▸ | CPB1 | P15086 | 1/20 | 0.59 |
| ▸ | CPA3 | P15088 | 1/20 | 0.59 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.59 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | TPH1 | P17752 | 1/20 | 0.50 |
| ▸ | GRB2 | P62993 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL27548157 | 1.00 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL27864433 | 1.00 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7248684 | 1.00 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL398714 | 1.00 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL13835334 | 0.98 | SLC7A5 (0.79) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29211050 | 0.95 | SLC7A5 (0.73) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL22556045 | 0.95 | SLC7A5 (0.73) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL13836013 | 0.95 | SLC7A5 (0.73) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL630407 | 0.95 | SLC7A5 (0.73) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3360080 | 0.93 | SLC7A5 (0.71) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150797-A1 | BIOCATALYTICAL PRODUCTION OF DIHYDROCHALCONES | SYMRISE AG (DE) | 2024-05-09 | — | — | US | disclosed |
| US-11884718-B2 | Potent zika virus-specific and cross-neutralizing monoclonal antibodies to zika and dengue viruses following ZIKV infection or vaccination | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2024-01-30 | — | — | US | disclosed |
| EP-4301865-A1 | BIOCATALYTICAL PRODUCTION OF DIHYDROCHALCONES | Symrise AG (DE) | 2024-01-10 | — | — | EP | disclosed |
| US-20230210141-A1 | Taste-Modulation of Cooling Agents in Beverages | WEI EDWARD T (US) | 2023-07-06 | — | — | US | disclosed |
| WO-2022184248-A1 | BIOCATALYTICAL PRODUCTION OF DIHYDROCHALCONES | SYMRISE AG (DE) | 2022-09-09 | — | — | WO | disclosed |
| US-20210238262-A1 | Potent Zika Virus-Specific and Cross-Neutralizing Monoclonal Antibodies to Zika and Dengue Viruses Following Zikv Infection or Vaccination | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| CN-106537145-B | Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment | 麦特博隆股份有限公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-110357942-A | A kind of two peptide combinations and the application in terms of enhancing CIK cell activity | 南京乐扬医药科技有限公司 | 2019-10-22 | — | — | CN | disclosed |
| US-20180291077-A1 | METHOD OF INSULIN PRODUCTION | HANMI PHARM. CO., LTD (KR) | 2018-10-11 | — | — | US | disclosed |
| EP-3341405-A1 | METHOD OF INSULIN PRODUCTION | Hanmi Pharm. Co., Ltd. (KR) | 2018-07-04 | — | — | EP | disclosed |
| WO-2004080920-A1 | HYDROPONIC PLANT NUTRIENT KIT AND METHOD OF USE | ADVANCED NUTRIENTS LTD. (CA) | 2004-09-23 | — | — | WO | disclosed |
| EP-0846127-A1 | ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY | Novartis AG (CH) | 1998-06-10 | — | — | EP | disclosed |
| CN-1151761-A | Subtilisin BPN' variants with reduced adsorption and increased hydrolysis | PROCTER & GAMBLE (US) | 1997-06-11 | — | — | CN | disclosed |
| WO-1997008193-A1 | ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |
| EP-0132999-B1 | PROCESS AND COMPOSITIONS FOR PREPARING PHENYLALANINE | RHONE-POULENC CHIMIE (FR) | 1992-01-15 | — | — | EP | disclosed |
| EP-0204826-A4 | HEAT STABILIZED PEPTIDE SWEETENERS. | JOYCE PATRICK JOSEPH | 1989-02-09 | — | — | EP | disclosed |
| EP-0204826-A1 | HEAT STABILIZED PEPTIDE SWEETENERS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1986-12-17 | — | — | EP | disclosed |
| WO-1986003378-A1 | HEAT STABILIZED PEPTIDE SWEETENERS | JOYCE PATRICK JOSEPH | 1986-06-19 | — | — | WO | disclosed |
| EP-0169937-A2 | Process for the preparation of alpha-L-aspartyl-L-phenylalanine alkyl esters | FARCHEMIA S.p.A. (IT) | 1986-02-05 | — | — | EP | disclosed |
| EP-0170148-A2 | Process for the preparation of alfa-L-aspartyl-L-phenylalanine alkyl esters | FARCHEMIA S.p.A. (IT) | 1986-02-05 | — | — | EP | disclosed |