Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.71 |
| ▸ | ALPI | P09923 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | XIAP | P98170 | 1/20 | 0.71 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.57 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.57 |
| ▸ | CPA1 | P15085 | 2/20 | 0.53 |
| ▸ | CPB1 | P15086 | 1/20 | 0.53 |
| ▸ | CPA3 | P15088 | 1/20 | 0.53 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.53 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.51 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 4/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL27808422 | 1.00 | SLC7A5 (0.71) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL17766088 | 1.00 | SLC7A5 (0.71) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL398714 | 0.93 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL27864433 | 0.93 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL1897792 | 0.93 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL27548157 | 0.93 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7248684 | 0.93 | SLC7A5 (0.81) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL13835334 | 0.92 | SLC7A5 (0.79) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL6033327 | 0.92 | SLC7A5 (0.85) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL6535507 | 0.92 | SLC7A5 (0.85) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2910932-B1 | Development and use of cysteine-labeled fluorescent probes of unbound analytes | FFA SCIENCES LLC (US) | 2018-10-31 | — | — | EP | disclosed |
| US-20180045742-A1 | DEVELOPMENT AND USE OF CYSTEINE-LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | FFA SCIENCES, LLC | 2018-02-15 | — | — | US | disclosed |
| US-9817004-B2 | Development and use of cysteine-labeled fluorescent probes of unbound analytes | Kleinfeld, Alan (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160146843-A1 | DEVELOPMENT AND USE OF CYSTEINE-LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | FFA SCIENCES, LLC | 2016-05-26 | — | — | US | disclosed |
| US-9134317-B2 | Development and use of cysteine-labeled fluorescent probes of unbound analytes | Kleinfeld, Alan (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2910932-A2 | Development and use of cysteine-labeled fluorescent probes of unbound analytes | Ffa Sciences, Llc (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2238431-B1 | DEVELOPMENT AND USE OF CYSTEINE - LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | FFA SCIENCES LLC (US) | 2014-12-03 | — | — | EP | disclosed |
| US-20100298162-A1 | DEVELOPMENT AND USE OF CYSTEINE-LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | FFA SCIENCES, LLC | 2010-11-25 | — | — | US | disclosed |
| EP-2238431-A1 | DEVELOPMENT AND USE OF CYSTEINE - LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | Ffa Sciences, Llc (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009092047-A1 | DEVELOPMENT AND USE OF CYSTEINE - LABELED FLUORESCENT PROBES OF UNBOUND ANALYTES | FFA SCIENCES, LLC (US) | 2009-07-23 | — | — | WO | disclosed |