Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18979228 | 0.82 | ERCC1 (0.42) | NOTUMHCRTR1HCRTR2 | |
| SCHEMBL14961974 | 0.78 | NOTUM (0.75) | NOTUMKEAP1 | |
| SCHEMBL18726009 | 0.74 | NOTUM (0.55) | NOTUMKEAP1HCRTR1HCRTR2 | |
| SCHEMBL18726002 | 0.71 | NOTUM (0.53) | NOTUMKEAP1HCRTR1HCRTR2 | |
| SCHEMBL2627224 | 0.71 | NOTUM (0.64) | NOTUMKEAP1 | |
| SCHEMBL1336092 | 0.71 | NOTUM (1.00) | NOTUMKEAP1 | |
| SCHEMBL30731222 | 0.71 | NOTUM (0.64) | NOTUMKEAP1 | |
| SCHEMBL29471927 | 0.70 | MAPK8 (0.56) | NOTUMKEAP1 | |
| SCHEMBL18979264 | 0.68 | DRD2 (0.50) | NOTUM | |
| SCHEMBL15642814 | 0.68 | DRD2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632255-B1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | claimed |