Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.44 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.44 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376239 | 0.85 | LMNA (0.45) | MAPK8MAPK10NOTUMKEAP1LMNA | |
| SCHEMBL18726009 | 0.83 | NOTUM (0.55) | MAPK8MAPK10NOTUMKEAP1 | |
| SCHEMBL14961974 | 0.82 | NOTUM (0.75) | NOTUMKEAP1 | |
| SCHEMBL14961830 | 0.80 | HTT (0.56) | NOTUMLMNAKMODHFRAGXT | |
| SCHEMBL27329825 | 0.80 | LMNA (0.71) | LMNAKMODHFRAGXTPLOD2 | |
| SCHEMBL12099625 | 0.79 | NOTUM (0.51) | MAPK8MAPK10NOTUMKEAP1MAPT | |
| SCHEMBL18726002 | 0.78 | NOTUM (0.53) | MAPK8MAPK10NOTUMKEAP1 | |
| SCHEMBL29471949 | 0.76 | AGXT (0.52) | MAPK8MAPK10LMNAKMODHFR | |
| SCHEMBL12524335 | 0.75 | NOTUM (0.45) | MAPK8MAPK10NOTUMKEAP1 | |
| SCHEMBL22466259 | 0.75 | LMNA (0.46) | LMNAKMODHFRAGXTPLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285850-B | Isoindoline compounds, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-04-22 | — | — | CN | disclosed |