Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735831 | 0.85 | HSD17B10 (0.42) | HSD17B10NPSR1MAPTMEN1KMT2A | |
| SCHEMBL18258606 | 0.85 | HSD17B10 (0.42) | HSD17B10NPSR1MAPTMEN1KMT2A | |
| Alanine SCHEMBL28071528 | 0.73 | GABRR1 (0.52) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Alanine SCHEMBL28071526 | 0.73 | GABRR1 (0.52) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Monoethanolamine SCHEMBL28219640 | 0.73 | GABRR1 (0.52) | GABRR1ALDH1A1TSHRTP53CYP1A2 | |
| Lactic Acid SCHEMBL1831319 | 0.71 | TP53 (0.61) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Lactic Acid SCHEMBL22346344 | 0.71 | TP53 (0.61) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Lactic Acid SCHEMBL27177897 | 0.71 | TP53 (0.61) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Methylmalonic Acid SCHEMBL5875088 | 0.71 | GABRR1 (0.50) | GABRR1ALDH1A1TSHRTP53SLC7A5 | |
| Monoethanolamine SCHEMBL3728867 | 0.69 | GABRR1 (0.48) | GABRR1HSD17B10TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170176470-A1 | DETECTION OF CARBOXYALKYLPYRROLE OR PENTYLPYRROLE ETHANOLAMINE PHOSPHOLIPIDS | UNIV CASE WESTERN RESERVE (US) | 2017-06-22 | — | — | US | disclosed |