Sugi Predict

Sugi Predict / Compounds / SCHEMBL18982153

SCHEMBL18982153

SCHEMBL18982153

OCc1ccc(Cl)c(CBr)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RECQL P46063 1/20 0.39
▸ TTR P02766 1/20 0.38
▸ CYP4F2 P78329 1/20 0.37
▸ CYP4A11 Q02928 1/20 0.37
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ HPGD P15428 1/20 0.35
▸ S1PR1 P21453 4/20 0.35
▸ IDO1 P14902 2/20 0.34
▸ PNMT P11086 2/20 0.33
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ SLC6A4 P31645 1/20 0.33
▸ SLC6A3 Q01959 1/20 0.33
▸ EGFR P00533 1/20 0.33
▸ TAAR1 Q96RJ0 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ XBP1 P17861 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31621229 0.85 RECQL (0.43) RECQLTTRNPC1RAB9ASMN1; SMN2
SCHEMBL30989341 0.83 RECQL (0.39) RECQLTTRCYP4F2CYP4A11NPC1
SCHEMBL28439761 0.81 IDO1 (0.35) TTRCYP4F2CYP4A11IDO1PNMT
SCHEMBL31460200 0.79 CYP4F2 (0.44) CYP4F2CYP4A11NPC1RAB9ASMN1; SMN2
SCHEMBL1245987 0.79 RECQL (0.39) RECQLTTRNPC1RAB9ASMN1; SMN2
SCHEMBL23647876 0.77 CA2 (0.33) RECQLTTRSLC6A2SLC6A4SLC6A3
SCHEMBL29790996 0.77 CA2 (0.33) RECQLTTRSLC6A2SLC6A4SLC6A3
SCHEMBL17508770 0.75 CYP4F2 (0.43) RECQLTTRCYP4F2CYP4A11SLC6A2
SCHEMBL92905 0.75 IDO1 (0.58) RECQLSMN1; SMN2S1PR1IDO1PNMT
SCHEMBL8878807 0.75 SLC6A2 (0.49) IDO1PNMTSLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388615-A9 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2025-12-25 — — US disclosed
US-20250066410-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2025-02-27 — — US disclosed
US-12084472-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists ARDELYX, INC. (US) 2024-09-10 — — US disclosed
US-20220306672-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2022-09-29 — — US disclosed
EP-3390382-B1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX INC (US) 2021-12-01 — — EP disclosed
EP-3390382-B1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX INC (US) 2021-12-01 — — EP disclosed
CN-108699028-B Substituted 4-phenylpyridines as non-systemic TGR5 agonists 阿德利克斯公司 2021-10-22 — — CN disclosed
US-10968246-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists ARDELYX, INC. (US) 2021-04-06 — — US disclosed
US-20200062795-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2020-02-27 — — US disclosed
US-10392413-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists ARDELYX, INC. (US) 2019-08-27 — — US disclosed
EP-3390382-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS Ardelyx, Inc. (US) 2018-10-24 — — EP disclosed
US-20170174718-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. 2017-06-22 — — US disclosed
US-20170174718-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. 2017-06-22 — — US disclosed
WO-2017106818-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2017-06-22 — — WO disclosed
US-20170174718-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. 2017-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066410-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-20170174718-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-20250388615-A9 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, FFAR3 RECQL 2868/4885TTR 824/4885CYP4F2 743/4885
US-20200062795-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-10968246-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-10392413-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-20220306672-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885
US-12084472-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists GPR119, GIPR, GLP1R RECQL 2947/4885TTR 1648/4885CYP4F2 722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.