Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 7/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | GCKR | Q14397 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649114 | 0.78 | TSHR (0.39) | SMN1; SMN2MLYCDRORCNR1H2NR1H3 | |
| SCHEMBL3434346 | 0.70 | SMN1; SMN2 (0.71) | SMN1; SMN2MLYCDRORCNPC1RAB9A | |
| SCHEMBL21176841 | 0.70 | DEGS1 (0.36) | RAB9A | |
| SCHEMBL3431607 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2MLYCDRORCRAB9ANR1H2 | |
| SCHEMBL17963963 | 0.69 | GABRP (0.34) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17742 | 0.69 | NR1H2 (0.42) | GCKGCKRNR1H2NR1H3 | |
| SCHEMBL15635468 | 0.69 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18275125 | 0.68 | KMT2A (0.50) | NR1H2NR1H3 | |
| SCHEMBL30496398 | 0.67 | KDM4E (0.48) | SMN1; SMN2AGBL2 | |
| Carbamic Acid SCHEMBL14800687 | 0.66 | DEGS1 (0.33) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411929-B1 | MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2011-05-11 | — | — | EP | claimed |