Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.76 |
| ▸ | RAB9A | P51151 | 5/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898437 | 0.88 | NPC1 (0.78) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL1898884 | 0.88 | NPC1 (0.78) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL13757469 | 0.85 | NPC1 (0.78) | NPC1RAB9AMAPTKMT2AAURKA | |
| SCHEMBL4255748 | 0.81 | NPC1 (0.67) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL1902091 | 0.81 | RAB9A (0.67) | NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4255743 | 0.79 | NPC1 (0.64) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL1899061 | 0.78 | GAA (0.56) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2300416 | 0.78 | NPC1 (1.00) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL13757472 | 0.76 | NPC1 (0.64) | NPC1RAB9AMAPTKMT2AAURKA | |
| SCHEMBL15133772 | 0.75 | NPC1 (0.59) | NPC1RAB9AMAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |