Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.84 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.84 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.84 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL28959450 | 1.00 | SIGMAR1 (0.84) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL27438559 | 0.94 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL18227057 | 0.92 | SIGMAR1 (0.91) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL13747483 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL15094315 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42178 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL4781849 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL20211416 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42615 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| Levmetamfetamine SCHEMBL727412 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190000834-A1 | INJECTABLE COMPOSITION AND A METHOD OF TREATMENT OF THE PHYSICAL ADDICTION | VERITA RESEARCH PTE LTD (AU) | 2019-01-03 | — | — | US | disclosed |
| WO-2017100863-A1 | INJECTABLE COMPOSITION AND A METHOD OF TREATMENT OF THE PHYSICAL ADDICTION | VERITA RESEARCH PTE LTD (AU) | 2017-06-22 | — | — | WO | disclosed |