Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.78 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 9/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 8/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MGMT | P16455 | 5/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Chloroguanine SCHEMBL64059 | 0.88 | DPP4 (1.00) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL28284949 | 0.87 | DPP4 (0.96) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL9183931 | 0.87 | DPP4 (0.96) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL9079950 | 0.87 | DPP4 (0.96) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL8715991 | 0.87 | DPP4 (0.96) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL9424255 | 0.83 | DPP4 (0.76) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL9226302 | 0.81 | DPP4 (0.68) | DPP4PDPK1GDACDK2MAP3K5 | |
| 6-Chloroguanine SCHEMBL18985251 | 0.75 | DPP4 (0.42) | DPP4PDPK1GDAHRH4 | |
| 6-Chloroguanine SCHEMBL17187927 | 0.74 | DPP4 (0.69) | DPP4CDK2CDK1CCNB1CCNA2 | |
| 6-Chloroguanine SCHEMBL7208346 | 0.72 | DPP4 (0.61) | DPP4PDPK1GDACDK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100849-A1 | 6-OXOPURINE PHOSPHORIBOSYL TRANSFERASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2017-06-22 | — | — | WO | disclosed |