Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 11/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 10/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Diaminopurine SCHEMBL2934952 | 0.88 | PDPK1 (0.59) | DPP4PDPK1GDAMGMTCDK2 | |
| 2,6-Diaminopurine SCHEMBL6241914 | 0.88 | PDPK1 (0.59) | DPP4PDPK1GDAMGMTCDK2 | |
| 2,6-Diaminopurine SCHEMBL10774603 | 0.88 | PDPK1 (0.59) | DPP4PDPK1GDAMGMTCDK2 | |
| Ribose (Furanose) SCHEMBL639319 | 0.82 | HSP90AB1 (0.40) | DPP4CYP1A2GMNNLMNATP53 | |
| Methylguanine SCHEMBL34851 | 0.82 | CDK1 (0.51) | MGMTCDK2CDK1CCNB1CCNA2 | |
| Ribose (Furanose) SCHEMBL8605925 | 0.81 | ADK (0.40) | CDK2CYP1A2GMNNLMNANFKB1 | |
| Ribose (Furanose) SCHEMBL17824409 | 0.81 | ADK (0.40) | CDK2CYP1A2GMNNLMNANFKB1 | |
| Ribose (Furanose) SCHEMBL4542672 | 0.81 | ADK (0.40) | CDK2CYP1A2GMNNLMNANFKB1 | |
| 6-Chloroguanine SCHEMBL10674719 | 0.81 | LMNA (0.40) | CYP1A2GMNNALDH1A1LMNATP53 | |
| 6-Chloroguanine SCHEMBL18241040 | 0.80 | TRPM2 (0.46) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702683-B1 | 06-SUBSTITUTED GUANINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN TREATING TUMOUR CELLS | CANCER REC TECH LTD (GB) | 2003-09-17 | — | — | EP | claimed |
| US-4728736-A | HERPES VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 1988-03-01 | — | — | US | disclosed |
| US-4543255-A | Carbocyclic analogs of purine 2'-deoxyribofuranosides | SOUTHERN RESEARCH INSTITUTE (US) | 1985-09-24 | — | — | US | disclosed |