Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.69 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29642936 | 1.00 | COMT (0.69) | COMTBCHEACHENPC1HPGD | |
| SCHEMBL18987262 | 0.92 | COMT (0.70) | COMTBCHEACHENPC1HPGD | |
| SCHEMBL29642900 | 0.92 | COMT (0.70) | COMTBCHEACHENPC1HPGD | |
| SCHEMBL29642820 | 0.91 | COMT (0.69) | COMTBCHEACHENPC1HPGD | |
| SCHEMBL18987018 | 0.91 | COMT (0.69) | COMTBCHEACHENPC1HPGD | |
| SCHEMBL18987094 | 0.89 | COMT (0.63) | COMTBCHEACHEFTO | |
| SCHEMBL18987105 | 0.84 | COMT (0.79) | COMTNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL29642891 | 0.84 | COMT (0.79) | COMTNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL20590973 | 0.84 | COMT (0.58) | COMTBCHEACHE | |
| SCHEMBL29642781 | 0.84 | COMT (0.58) | COMTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | claimed |
| US-11008282-B2 | Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease | KOESTER HUBERT (CH) | 2021-05-18 | — | — | US | claimed |
| US-20180370906-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-12-27 | — | — | US | claimed |
| EP-3390351-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-10-24 | — | — | EP | claimed |
| WO-2017103278-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | CAPROTEC BIOANALYTICS GMBH (DE) | 2017-06-22 | — | — | WO | claimed |
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | disclosed |
| CN-108698984-B | Bicyclic compounds for use as medicaments, in particular for the treatment of parkinson's disease | H·科斯特 | 2022-05-10 | — | — | CN | disclosed |
| EP-3390351-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017103278-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | CAPROTEC BIOANALYTICS GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370906-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | COMT, DBH, PNMT | COMT 1/4885BCHE 15/4885ACHE 91/4885 |
| US-11008282-B2 | Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease | COMT, PNMT, DBH | COMT 1/4885BCHE 11/4885ACHE 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.