Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 9/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.31 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31514942 | 1.00 | COMT (0.76) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31514945 | 0.87 | COMT (1.00) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18987117 | 0.87 | COMT (1.00) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31514943 | 0.86 | COMT (0.55) | COMTHPGDESR1CYP1A2ALDH1A1 | |
| SCHEMBL31514932 | 0.86 | COMT (0.55) | COMTHPGDESR1CYP1A2ALDH1A1 | |
| SCHEMBL18987105 | 0.86 | COMT (0.79) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29642891 | 0.86 | COMT (0.79) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18986811 | 0.82 | COMT (0.72) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29642900 | 0.81 | COMT (0.70) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18987262 | 0.81 | COMT (0.70) | COMTHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | claimed |
| US-11008282-B2 | Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease | KOESTER HUBERT (CH) | 2021-05-18 | — | — | US | claimed |
| US-20180370906-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-12-27 | — | — | US | claimed |
| EP-3390351-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-10-24 | — | — | EP | claimed |
| WO-2017103278-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | CAPROTEC BIOANALYTICS GMBH (DE) | 2017-06-22 | — | — | WO | claimed |
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | disclosed |
| CN-108698984-B | Bicyclic compounds for use as medicaments, in particular for the treatment of parkinson's disease | H·科斯特 | 2022-05-10 | — | — | CN | disclosed |
| US-11008282-B2 | Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease | KOESTER HUBERT (CH) | 2021-05-18 | — | — | US | disclosed |
| US-20180370906-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-12-27 | — | — | US | disclosed |
| EP-3390351-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | Koester, Hubert (CH) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017103278-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | CAPROTEC BIOANALYTICS GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017103278-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | CAPROTEC BIOANALYTICS GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370906-A1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | COMT, DBH, PNMT | COMT 1/4885HPGD 794/4885NPC1 2630/4885 |
| US-11008282-B2 | Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease | COMT, PNMT, DBH | COMT 1/4885HPGD 829/4885NPC1 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.