Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30405953 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1KMT2AMEN1MGAM | |
| SCHEMBL29050073 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1KMT2AMEN1MGAM | |
| SCHEMBL17362538 | 0.82 | TARBP2 (0.42) | CYP2C19KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL25210087 | 0.80 | HPGD (0.42) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL30969148 | 0.80 | HPGD (0.42) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7863801 | 0.78 | ALDH1A1 (0.44) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL15897838 | 0.77 | DPP4 (0.42) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 | |
| SCHEMBL12018710 | 0.77 | GAA (0.40) | CYP1A2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL17224823 | 0.76 | GSK3B (0.37) | KDM4EALDH1A1POLB | |
| SCHEMBL3695889 | 0.75 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699065-B | Tricyclic compounds and compositions as kinase inhibitors | 诺华股份有限公司 | 2021-08-31 | — | — | CN | disclosed |
| EP-3390404-B1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2021-07-21 | — | — | EP | disclosed |
| EP-3390404-B1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2021-07-21 | — | — | EP | disclosed |
| US-10377770-B2 | Tricyclic compounds and compositions as kinase inhibitors | NOVARTIS AG (CH) | 2019-08-13 | — | — | US | disclosed |
| US-20180362542-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2018-12-20 | — | — | US | disclosed |
| EP-3390404-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017103824-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017103824-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362542-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | BRAF, RAF1, MAP3K1 | CYP1A2 1165/4885CYP3A4 2073/4885CYP2C19 1507/4885 |
| US-10377770-B2 | Tricyclic compounds and compositions as kinase inhibitors | BRAF, RAF1, MAP3K1 | CYP1A2 1165/4885CYP3A4 2073/4885CYP2C19 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.