Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21997016 | 0.98 | KDM4A (0.44) | KDM4AKDM4CKISS1REPHX1KDM4E | |
| SCHEMBL17093613 | 0.94 | KDM4A (0.39) | KDM4AKDM4CKISS1RKDM4ESMN1; SMN2 | |
| SCHEMBL2721332 | 0.86 | PRMT3 (0.37) | KDM4AKDM4CMEN1HTTKMT2A | |
| Hydrochloric Acid SCHEMBL837377 | 0.84 | KDM4A (0.36) | KDM4AKDM4CMEN1HTTKMT2A | |
| SCHEMBL5791276 | 0.80 | TSHR (0.40) | EPHX1GAAALDH1A1 | |
| SCHEMBL5312463 | 0.79 | EPHX1 (0.39) | EPHX1KDM4EALDH1A1 | |
| SCHEMBL5791555 | 0.79 | EPHX1 (0.39) | EPHX1KDM4EALDH1A1 | |
| SCHEMBL5618639 | 0.79 | POLB (0.37) | ALDH1A1 | |
| SCHEMBL29029803 | 0.78 | AKR1B1 (0.39) | KDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL360638 | 0.78 | GPR84 (0.34) | MEN1HTTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390382-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | Ardelyx, Inc. (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106818-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2017-06-22 | — | — | WO | disclosed |