SCHEMBL1899282

SCHEMBL1899282

COC(=O)c1ncccc1NC(=O)Cc1ccccc1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.50
ANO1 Q5XXA6 2/20 0.49
TP53 P04637 1/20 0.47
KDM4E B2RXH2 1/20 0.46
KMT2A Q03164 1/20 0.46
LMNA P02545 2/20 0.46
HTT P42858 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MAPK8 P45983 1/20 0.45
MAPK9 P45984 1/20 0.45
MAPK10 P53779 1/20 0.45
MAPK1 P28482 1/20 0.45
GAA P10253 1/20 0.45
CSF1R P07333 1/20 0.45
PDGFRB P09619 1/20 0.45
KIT P10721 1/20 0.45
PDGFRA P16234 1/20 0.45
FLT3 P36888 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1168830 0.84 HSD17B13 (0.53) BRD4LMNAALDH1A1MAPTMAPK8
SCHEMBL2303688 0.82 ANO1 (0.48) ANO1TP53KDM4EKMT2ALMNA
SCHEMBL8692725 0.79 BRD4 (0.58) BRD4KDM4EKMT2ALMNAALDH1A1
SCHEMBL1169159 0.78 BRD4 (0.56) BRD4KDM4EKMT2ALMNAALDH1A1
SCHEMBL1892783 0.78 POLQ (0.55) ANO1CSF1RPDGFRBKITPDGFRA
SCHEMBL9957265 0.78 L3MBTL1 (0.46) KDM4ELMNAHTTALDH1A1TDP1
SCHEMBL2346222 0.77 L3MBTL1 (0.55) HTTALDH1A1TDP1GAA
SCHEMBL9957557 0.77 GRM4 (0.45)
SCHEMBL1169145 0.75 GALR3 (0.56) BRD4KMT2ALMNAHTTALDH1A1
SCHEMBL13818079 0.75 BRD4 (0.66) BRD4KDM4EKMT2ALMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110201501-A1 Substituted Pyridines Having a Herbicidal Effect BASF SE (DE) 2011-08-18 US disclosed
WO-2011057942-A1 INSECTICIDAL METHODS USING PYRIDINE COMPOUNDS BASF SE (DE) 2011-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110201501-A1 Substituted Pyridines Having a Herbicidal Effect DDT, PNPO, HPD BRD4 1596/4885ANO1 2817/4885TP53 1664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.