Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 6/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 6/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 1.00 |
| ▸ | DRD1 | P21728 | 6/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 6/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 6/20 | 1.00 |
| ▸ | DRD3 | P35462 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | GFER | P55789 | 3/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.76 |
| ▸ | LMNA | P02545 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpromazine SCHEMBL18994 | 1.00 | CHRM2 (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Methylpromazine SCHEMBL29354434 | 1.00 | CHRM2 (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Methylpromazine SCHEMBL2774391 | 0.98 | CHRM2 (0.97) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL6944155 | 0.89 | HTR1A (0.80) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL2615384 | 0.89 | HTR1A (0.80) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Methylpromazine SCHEMBL719590 | 0.88 | GFER (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Ethopropazine SCHEMBL3690174 | 0.88 | HSD17B10 (0.80) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Methylpromazine SCHEMBL409663 | 0.88 | GFER (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Methylpromazine SCHEMBL21293802 | 0.88 | GFER (0.82) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL13284571 | 0.88 | CHRM2 (0.78) | CHRM2HTR1AADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8897 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| US-20250288591-A1 | TRIMEPRAZINE FOR USE IN TREATING TRIGEMINAL NEURALGIA AND FOR REDUCING PAIN RELATED THERETO | UNDAUNTED BIO, INC. (US) | 2025-09-18 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| US-20250134903-A1 | COMPOSITIONS AND METHODS FOR TREATING PAIN | UNDAUNTED BIO, INC. (US) | 2025-05-01 | — | — | US | claimed |
| WO-2025082959-A1 | A PHENOTHIAZINE-RELATED COMPOUND CONJUGATED TO A PEPTIDE | UNIVERSITY OF ULSTER (GB) | 2025-04-24 | — | — | WO | claimed |
| US-20250057783-A1 | ORAL FILMS OF ANTIPRURITIC DRUGS | LAURUS LABS LTD (IN) | 2025-02-20 | — | — | US | claimed |
| WO-2024229174-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2024-11-07 | — | — | WO | claimed |
| EP-4456873-A1 | ORAL FILMS OF ANTIPRURITIC DRUGS | Laurus Labs Limited (IN) | 2024-11-06 | — | — | EP | claimed |
| WO-1989005641-A1 | DEXTROMETHORPHAN POTENTIATOR FOR ANTICONVULSANT COMPOSITION AND METHOD | PONTECORVO MICHAEL J (US) | 1989-06-29 | — | — | WO | claimed |
| EP-0305008-A2 | Tumor or cancer cell killing therapy and agents useful therefor | OXI-GENE, INC. (US) | 1989-03-01 | — | — | EP | claimed |
| US-4749700-A | NASAL ADMINISTRATION LOWER DOSAGE | NASTECH PHARMACEUTICAL CO, INC. (US) | 1988-06-07 | — | — | US | claimed |
| EP-0233932-A4 | ANTICONVULSANT COMPOSITIONS AND METHOD. | UNIV NEW YORK (US) | 1988-04-26 | — | — | EP | claimed |
| EP-0233932-A1 | ANTICONVULSANT COMPOSITIONS AND METHOD | NEW YORK UNIVERSITY (US) | 1987-09-02 | — | — | EP | claimed |
| WO-1987001036-A1 | ANTICONVULSANT COMPOSITIONS AND METHOD | NEW YORK UNIVERSITY (US) | 1987-02-26 | — | — | WO | claimed |
| US-4407800-A | TRYPANOCIDES | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1983-10-04 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | claimed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | claimed |