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Methylpromazine

Methylpromazine

SCHEMBL21293802

CC(=O)[C@H](O)[C@@H](O)C(C)=O.CC(CN(C)C)CN1c2ccccc2Sc2ccccc21

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Methylpromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HRH1 known ✓ P35367 2/20 0.53
▸ GFER P55789 2/20 0.82
▸ CHRM2 P08172 6/20 0.78
▸ HTR1A P08908 6/20 0.78
▸ CHRM1 P11229 6/20 0.78
▸ ADRA1A P35348 6/20 0.78
▸ OPRM1 P35372 6/20 0.78
▸ DRD3 P35462 6/20 0.78
▸ KCNH2 Q12809 6/20 0.78
▸ ADRA2A P08913 5/20 0.78
▸ DRD1 P21728 5/20 0.78
▸ SLC6A2 P23975 4/20 0.78
▸ SLC6A4 P31645 4/20 0.78
▸ TBXA2R P21731 3/20 0.78
▸ SLC6A3 Q01959 2/20 0.78
▸ HRH3 Q9Y5N1 2/20 0.78
▸ ABCB11 O95342 1/20 0.78
▸ CYP2D6 P10635 6/20 0.62
▸ LMNA P02545 5/20 0.61
▸ PTGS1 P23219 4/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylpromazine SCHEMBL719590 0.90 GFER (1.00) GFERCHRM2HTR1ACHRM1ADRA1A
Methylpromazine SCHEMBL409663 0.90 GFER (1.00) GFERCHRM2HTR1ACHRM1ADRA1A
Methylpromazine SCHEMBL29354434 0.88 CHRM2 (1.00) GFERCHRM2HTR1ACHRM1ADRA1A
Methylpromazine SCHEMBL18994 0.88 CHRM2 (1.00) GFERCHRM2HTR1ACHRM1ADRA1A
Methylpromazine SCHEMBL18993 0.88 CHRM2 (1.00) GFERCHRM2HTR1ACHRM1ADRA1A
Methylpromazine SCHEMBL2774391 0.87 CHRM2 (0.97) GFERCHRM2HTR1ACHRM1ADRA1A
SCHEMBL21318406 0.83 HTR1A (0.70) GFERCHRM2HTR1ACHRM1ADRA1A
Levomepromazine SCHEMBL27701483 0.80 LMNA (0.88) GFERCHRM2HTR1ACHRM1ADRA1A
Levomepromazine SCHEMBL15789013 0.80 CHRM2 (0.82) GFERCHRM2HTR1ACHRM1ADRA1A
Levomepromazine SCHEMBL15789014 0.80 CHRM2 (0.82) GFERCHRM2HTR1ACHRM1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210393645-A1 TREATMENT FOR PROGRESSIVE MULTIPLE SCLEROSIS UTI LIMITED PARTNERSHIP (CA) 2021-12-23 — — US disclosed
US-20190262353-A1 TREATMENT FOR PROGRESSIVE MULTIPLE SCLEROSIS UTI LIMITED PARTNERSHIP (CA) 2019-08-29 — — US disclosed