Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28428414 | 0.68 | CHRM2 (0.55) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18583291 | 0.68 | RIPK1 (0.42) | — | |
| SCHEMBL9430009 | 0.67 | CYP1B1 (0.50) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4142273 | 0.66 | MAOB (0.56) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14542315 | 0.66 | CHRM2 (0.46) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19222408 | 0.65 | RIPK1 (0.39) | — | |
| SCHEMBL24447710 | 0.64 | BRD4 (0.47) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19976225 | 0.64 | ALOX5 (0.54) | CYP19A1ALOX5NPC1RAB9AMAOB | |
| SCHEMBL7848655 | 0.63 | CHRM2 (0.51) | GRM4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10279116 | 0.63 | QPCT (0.43) | GRM4CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682953-B2 | Amide compounds, compositions and applications thereof | ADVINUS THERAPEUTICS LIMITED (IN) | 2017-06-20 | — | — | US | disclosed |