Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787544 | 0.75 | HCRTR1 (0.33) | HCRTR1 | |
| SCHEMBL25195426 | 0.74 | OPRD1 (0.49) | OPRM1OPRK1 | |
| SCHEMBL30395153 | 0.74 | OPRD1 (0.49) | OPRM1OPRK1 | |
| SCHEMBL18878836 | 0.74 | OPRD1 (0.49) | OPRM1OPRK1 | |
| SCHEMBL16445075 | 0.74 | OPRD1 (0.49) | OPRM1OPRK1 | |
| SCHEMBL18878843 | 0.70 | DRD2 (0.38) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL20306868 | 0.67 | HCRTR1 (0.55) | OPRM1HCRTR1OPRK1 | |
| SCHEMBL10072676 | 0.67 | HCRTR1 (0.55) | OPRM1HCRTR1OPRK1 | |
| SCHEMBL10072236 | 0.67 | HCRTR1 (0.53) | OPRM1HCRTR1OPRK1 | |
| SCHEMBL20306867 | 0.67 | HCRTR1 (0.53) | OPRM1HCRTR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682936-B2 | Morphan and morphinan analogues, and methods of use | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-06-20 | — | — | US | disclosed |