Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15786417 | 0.82 | KMT2A (0.55) | NR1I2USP2ALDH1A1TSHRLMNA | |
| SCHEMBL18994950 | 0.79 | LMNA (0.44) | LMNAKCNN4NPC1 | |
| SCHEMBL15783484 | 0.77 | NR1I2 (0.55) | NR1I2 | |
| SCHEMBL19836576 | 0.77 | NR1I2 (0.42) | NR1I2USP2ALDH1A1TSHRLMNA | |
| SCHEMBL4203800 | 0.77 | ATM (0.55) | USP2ALDH1A1TSHRMAPTTP53 | |
| SCHEMBL4211677 | 0.75 | KCNN4 (0.66) | NR1I2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL17550642 | 0.72 | LMNA (0.43) | ALDH1A1TSHRLMNAHTTMAPT | |
| SCHEMBL18066884 | 0.72 | LRRK2 (0.39) | USP2ALDH1A1TSHRLMNAHTT | |
| SCHEMBL10066944 | 0.72 | LMNA (0.64) | ALDH1A1LMNAHTTMAPTTP53 | |
| SCHEMBL17708385 | 0.69 | LRRK2 (0.43) | USP2ALDH1A1TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |