Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995752 | 0.79 | TAAR1 (0.47) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL3589541 | 0.78 | TAAR1 (0.47) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL22441312 | 0.78 | TAAR1 (0.47) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL21378558 | 0.78 | TAAR1 (0.47) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL7987728 | 0.76 | TAAR1 (0.43) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL7420387 | 0.75 | CA1 (0.39) | TAAR1SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2600698 | 0.75 | CYP2D6 (0.43) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 | |
| SCHEMBL9570349 | 0.73 | MEN1 (0.41) | TAAR1SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL18995774 | 0.72 | ALDH1A1 (0.51) | TAAR1KMT2AMEN1KDM4EGMNN | |
| SCHEMBL17372882 | 0.71 | MEN1 (0.40) | TAAR1SIGMAR1SLC18A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682944-B2 | Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors | PIRAMAL IMAGING SA (CH) | 2017-06-20 | — | — | US | disclosed |