Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.55 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10062064 | 1.00 | SIGMAR1 (0.55) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL1697045 | 0.87 | SIGMAR1 (0.64) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL12289294 | 0.81 | SLC6A4 (0.61) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A4 | |
| SCHEMBL172645 | 0.81 | SLC6A4 (0.61) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A4 | |
| SCHEMBL9341390 | 0.81 | SLC6A4 (0.61) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A4 | |
| SCHEMBL1764932 | 0.79 | TAAR1 (0.55) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL10797818 | 0.79 | TAAR1 (0.55) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL2629129 | 0.79 | SIGMAR1 (0.55) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL21550512 | 0.79 | TAAR1 (0.55) | SIGMAR1TAAR1SLC18A2EPHX1SLC6A2 | |
| SCHEMBL1396350 | 0.79 | MAPK1 (0.57) | SIGMAR1TAAR1SLC18A2EPHX1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020118163-A1 | DECARBOXYLASE INHIBITORS FOR TREATING PARKINSON'S DISEASE | KINTAI THERAPEUTICS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |
| US-9682944-B2 | Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors | PIRAMAL IMAGING SA (CH) | 2017-06-20 | — | — | US | disclosed |