Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.57 |
| ▸ | GSK3B | P49841 | 8/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18999590 | 1.00 | MAPK14 (0.57) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL12627476 | 0.89 | MAPK14 (0.59) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL18431826 | 0.89 | MAPK14 (0.59) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL12627466 | 0.82 | MAPK14 (0.60) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL18431264 | 0.82 | MAPK14 (0.60) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL18431263 | 0.81 | MAPK14 (0.62) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL12627459 | 0.81 | MAPK14 (0.62) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL12627468 | 0.79 | MAPK14 (0.63) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL18431266 | 0.79 | MAPK14 (0.63) | MAPK14MAPK10MAPK8GSK3BPIP5K1C | |
| SCHEMBL21068073 | 0.75 | MAPK10 (1.00) | MAPK14MAPK10MAPK8GSK3BPIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662195-B2 | Protein kinase conjugates and inhibitors | CELGENE CAR LLC (BM) | 2020-05-26 | — | — | US | disclosed |
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | CELGENE CAR LLC (BM) | 2017-06-22 | — | — | US | disclosed |
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | CELGENE CAR LLC (BM) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | MAP3K20, ADK, TTK | MAPK14 285/4885MAPK10 294/4885MAPK8 214/4885 |
| US-10662195-B2 | Protein kinase conjugates and inhibitors | MAP3K20, ADK, TTK | MAPK14 285/4885MAPK10 294/4885MAPK8 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.