Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.71 |
| ▸ | CNR1 | P21554 | 2/20 | 0.66 |
| ▸ | CNR2 | P34972 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.63 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898992 | 0.95 | NPC1 (0.68) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1898696 | 0.94 | TASP1 (0.81) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1903539 | 0.92 | TASP1 (0.65) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1899685 | 0.84 | NPSR1 (0.85) | TASP1CNR1CNR2NPSR1MAPT | |
| SCHEMBL3064847 | 0.84 | NPC1 (1.00) | NPC1TASP1NPSR1MAPTMAPK1 | |
| SCHEMBL10069051 | 0.83 | TASP1 (1.00) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1900846 | 0.81 | NPC1 (0.70) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1899142 | 0.80 | NPC1 (0.67) | NPC1TASP1CNR1CNR2NPSR1 | |
| SCHEMBL1903709 | 0.78 | MAPT (0.68) | NPC1CNR1CNR2NPSR1MAPT | |
| SCHEMBL3804271 | 0.77 | NPC1 (0.58) | NPC1TASP1CNR1CNR2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |