Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | CNR2 | P34972 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GRN | P28799 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900620 | 0.88 | MAPK14 (0.59) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1897017 | 0.87 | BRAF (0.58) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1903600 | 0.86 | KDM4E (0.60) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6059993 | 0.84 | POLB (0.58) | MAPTMAPK14CNR2CNR1NPSR1 | |
| SCHEMBL4425426 | 0.84 | NPSR1 (0.59) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL66874 | 0.81 | MAPK14 (1.00) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4257557 | 0.80 | AAK1 (0.55) | MAPTMAPK14CNR2CNR1NPSR1 | |
| SCHEMBL1899685 | 0.79 | NPSR1 (0.85) | MAPTCNR2CNR1CYP1A2CYP2D6 | |
| SCHEMBL1898147 | 0.79 | LMNA (0.55) | MAPK14NPSR1MEN1KMT2ABRAF | |
| SCHEMBL4071121 | 0.78 | CNR1 (0.46) | MAPTMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |