Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | VPS4B | O75351 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903598 | 1.00 | HTR1A (0.51) | HTR1AHTR1BHTR1DSLC6A4HTR1F | |
| SCHEMBL1899834 | 1.00 | HTR1A (0.51) | HTR1AHTR1BHTR1DSLC6A4HTR1F | |
| SCHEMBL6530651 | 0.87 | HTR1A (0.51) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL12637107 | 0.87 | HTR1A (0.51) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL14624292 | 0.87 | HTR1B (0.53) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL24408396 | 0.86 | HTR1B (0.57) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL8531461 | 0.86 | KMT2A (0.62) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL8527422 | 0.85 | HTR1A (0.49) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL7102071 | 0.85 | HTR1B (0.56) | HTR1AHTR1BHTR1DMEN1KMT2A | |
| SCHEMBL834331 | 0.84 | MEN1 (0.53) | HTR1AHTR1BHTR1DMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |
| WO-2005033099-A2 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS; PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS THEREOF | GLENMARK PHARMACEUTICALS LTD. (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2005023799-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-03-17 | — | — | WO | disclosed |