Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531461 | 0.90 | KMT2A (0.62) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL12637107 | 0.87 | HTR1A (0.51) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL8530386 | 0.85 | KMT2A (0.59) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL1899834 | 0.85 | HTR1A (0.51) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL14624292 | 0.85 | HTR1B (0.53) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL6530651 | 0.85 | HTR1A (0.51) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL1903598 | 0.85 | HTR1A (0.51) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL1899835 | 0.85 | HTR1A (0.51) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL3791546 | 0.84 | HTR1B (0.77) | HTR1BHTR1AHTR1DKMT2AMEN1 | |
| SCHEMBL2356044 | 0.84 | HTR1B (0.77) | HTR1BHTR1AHTR1DKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674621-B1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | VERNALIS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |
| EP-0591280-A1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000086-A1 | USE OF TETRAHYDROCARBAZONE DERIVATIVES AS 5HT1 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | disclosed |