Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
| ▸ | HTR3B | O95264 | 1/20 | 0.55 |
| ▸ | HMGCR | P04035 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902186 | 0.84 | HTR4 (0.61) | HTR4KCNH2DRD2DRD3CYP3A4 | |
| SCHEMBL5391875 | 0.83 | HTR4 (0.63) | HTR4KCNH2 | |
| SCHEMBL10412207 | 0.83 | HTR4 (0.64) | HTR4KCNH2 | |
| SCHEMBL1897607 | 0.83 | HTR4 (0.69) | HTR4KCNH2DRD2DRD3DRD4 | |
| SCHEMBL9021814 | 0.80 | DRD4 (0.67) | HTR4DRD2DRD3DRD4CYP2D6 | |
| SCHEMBL9021834 | 0.80 | DRD4 (0.67) | HTR4DRD2DRD3DRD4CYP2D6 | |
| SCHEMBL1899999 | 0.80 | HTR4 (0.72) | HTR4KCNH2DRD2DRD3CYP3A4 | |
| SCHEMBL8054851 | 0.80 | HTR4 (0.77) | HTR4KCNH2 | |
| SCHEMBL2739065 | 0.79 | HTR4 (0.61) | HTR4KCNH2DRD2DRD3DRD4 | |
| Water SCHEMBL9721598 | 0.79 | HTR4 (0.76) | HTR4KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42412-E1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20030216387-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS | 2003-11-20 | — | — | US | disclosed |
| US-20020025970-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | ARYX THERAPEUTICS, INC. | 2002-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025970-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | GRPR, HRH2, FABP6 | HTR4 565/4885KCNH2 1833/4885DRD2 3212/4885 |
| US-20030216387-A1 | Materials and methods for the treatment of gastroesophageal reflux disease | GRPR, HRH2, FABP6 | HTR4 565/4885KCNH2 1833/4885DRD2 3212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.