Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.62 |
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 5/20 | 0.62 |
| ▸ | EEF2K | O00418 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558296 | 0.99 | NPC1 (0.60) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL19000383 | 0.96 | NPC1 (0.61) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL18537646 | 0.80 | NPC1 (0.41) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL18537589 | 0.78 | ALDH1A1 (0.59) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL14955121 | 0.77 | NPC1 (0.81) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL29858907 | 0.77 | NPC1 (1.00) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL425467 | 0.77 | NPC1 (1.00) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL13154828 | 0.77 | KDM4E (0.63) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL19769212 | 0.75 | RAB9A (0.97) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL14954806 | 0.75 | NPC1 (0.78) | NPC1RAB9AKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181568-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |