Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19000961 | 1.00 | GAA (0.35) | GAAHSD11B1KDM4EHTTHPGD | |
| SCHEMBL19001117 | 0.84 | ALDH1A1 (0.35) | GAAHSD11B1KDM4EHPGDALDH1A1 | |
| SCHEMBL19001017 | 0.84 | ALDH1A1 (0.35) | GAAHSD11B1KDM4EHPGDALDH1A1 | |
| SCHEMBL19012390 | 0.83 | KDM4E (0.51) | GAAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL19012688 | 0.83 | KDM4E (0.51) | GAAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL19001101 | 0.81 | ALDH1A1 (0.42) | HSD11B1KDM4EHTTALDH1A1LMNA | |
| SCHEMBL19000980 | 0.81 | ALDH1A1 (0.42) | HSD11B1KDM4EHTTALDH1A1LMNA | |
| SCHEMBL19001008 | 0.81 | ALDH1A1 (0.34) | HSD11B1KDM4EHTTHPGDSMN1; SMN2 | |
| SCHEMBL19001085 | 0.81 | ALDH1A1 (0.34) | HSD11B1KDM4EHTTHPGDSMN1; SMN2 | |
| SCHEMBL10202723 | 0.80 | HSD11B1 (0.38) | HSD11B1SMN1; SMN2ALDH1A1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938292-B2 | Quinoline derivatives as SMO inhibitors | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-10 | — | — | US | disclosed |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | SMO, GLI1, SHH | GAA 2952/4885HSD11B1 3620/4885KDM4E 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.