Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15942803 | 0.83 | YTHDC1 (0.65) | YTHDC1NTRK1PAK1FLT3JAK2 | |
| SCHEMBL2468351 | 0.83 | YTHDC1 (0.65) | YTHDC1NTRK1PAK1FLT3JAK2 | |
| SCHEMBL13386937 | 0.82 | YTHDC1 (0.63) | YTHDC1NTRK1PAK1FLT3JAK2 | |
| SCHEMBL1141823 | 0.82 | KDM4E (0.63) | YTHDC1NTRK1FLT3DYRK1ANTRK3 | |
| SCHEMBL5525195 | 0.81 | SMN1; SMN2 (0.53) | NTRK1DYRK1A | |
| SCHEMBL953396 | 0.81 | PRKAG1 (0.55) | — | |
| SCHEMBL13387003 | 0.81 | YTHDC1 (0.61) | YTHDC1NTRK1PAK1FLT3JAK2 | |
| SCHEMBL4520668 | 0.80 | FLT3 (0.55) | FLT3DYRK1ANTRK3CCNA2CDK2 | |
| SCHEMBL5945808 | 0.80 | FLT3 (0.70) | FLT3JAK2JAK1DYRK1ANTRK3 | |
| SCHEMBL7522062 | 0.80 | SMN1; SMN2 (0.69) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760285-B1 | INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF | SAMUMED LLC (US) | 2017-06-21 | — | — | EP | disclosed |