Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 16/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 16/20 | 0.51 |
| ▸ | BMPR1A | P36894 | 14/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 13/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3312583 | 0.87 | CYP11B1 (0.64) | CYP17A1CYP1A2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL23601553 | 0.84 | TRIM24 (0.56) | TRIM24ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL8999096 | 0.82 | TRIM24 (0.49) | TRIM24ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL745958 | 0.82 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL1899211 | 0.82 | LMNA (0.55) | TRIM24ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL24721524 | 0.80 | TRIM24 (0.50) | TRIM24ACVRL1ACVR1BMPR1ABMPR1B | |
| SCHEMBL27647972 | 0.78 | PARP10 (0.41) | CYP11B1CYP11B2PARP10PARP11 | |
| SCHEMBL769062 | 0.77 | CYP11B1 (0.78) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL769234 | 0.76 | ACVRL1 (0.71) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL753680 | 0.74 | CYP11B1 (0.73) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |