Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.79 |
| ▸ | PLAUR | Q03405 | 6/20 | 0.70 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | APAF1 | O14727 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499325 | 0.89 | PLAU (1.00) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL30019219 | 0.89 | PLAU (1.00) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL19002885 | 0.83 | PLAU (0.75) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL12698763 | 0.83 | PLAUR (1.00) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL12499165 | 0.81 | PLAU (0.84) | PLAUPLAURNTRK1EHMT2MAPT | |
| SCHEMBL12498973 | 0.80 | PLAU (0.83) | PLAUPLAURNTRK1EHMT2MEN1 | |
| SCHEMBL17874500 | 0.79 | PLAU (0.81) | PLAUPLAURNTRK1EHMT2MAPT | |
| SCHEMBL18484962 | 0.78 | PLAU (0.80) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL13284987 | 0.77 | NTRK1 (1.00) | PLAUPLAURNTRK1EHMT2GSK3B | |
| SCHEMBL16622147 | 0.76 | NTRK1 (0.90) | PLAUPLAURNTRK1EHMT2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687491-B1 | Compositions and methods of targeting mutant K-Ras | NANTBIOSCIENCE, INC. (US) | 2017-06-27 | — | — | US | disclosed |