Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9937975 | 0.92 | YTHDC1 (0.38) | YTHDC1SMN1; SMN2HDAC1ATRCYP3A4 | |
| SCHEMBL10008246 | 0.92 | YTHDC1 (0.38) | YTHDC1SMN1; SMN2HDAC1ATRCYP3A4 | |
| SCHEMBL16229481 | 0.86 | YTHDC1 (0.35) | YTHDC1HDAC1ATRCYP3A4 | |
| SCHEMBL30076448 | 0.85 | YTHDC1 (0.34) | YTHDC1HDAC1ATRHRH3FLT3 | |
| SCHEMBL9936683 | 0.85 | YTHDC1 (0.34) | YTHDC1HDAC1ATRHRH3FLT3 | |
| SCHEMBL19206330 | 0.84 | YTHDC1 (0.39) | YTHDC1SMN1; SMN2HDAC1ATRCYP3A4 | |
| SCHEMBL2673005 | 0.84 | YTHDC1 (0.41) | YTHDC1SMN1; SMN2HDAC1ATRCYP3A4 | |
| SCHEMBL9937313 | 0.83 | YTHDC1 (0.44) | YTHDC1 | |
| SCHEMBL9937867 | 0.83 | HDAC1 (0.37) | YTHDC1HDAC1ATRCNR2FLT3 | |
| SCHEMBL2113717 | 0.83 | YTHDC1 (0.38) | YTHDC1SMN1; SMN2HDAC1ATRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3978500-B1 | PROCESS FOR THE PREPARATION OF TRICYCLIC PI3K INHIBITOR COMPOUNDS | GENENTECH INC (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3389662-B1 | PROCESS FOR THE PREPARATION OF TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS FOR USING THE SAME FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-12-01 | — | — | EP | disclosed |
| WO-2017106647-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS FOR USING THE SAME FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-06-22 | — | — | WO | disclosed |